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ADDITIVES. Just tap water
OxyBreeth — Your Compact, On-Demand Antibacterial Water Generator.
ADDITIVES. Just tap water
The Proof. 99%+ Bacterial Reduction in Lab Testing Within 30 Seconds.
Less spent on bottles, packets, and mouthwash tablets Again and Again.
The research behind everyday care.
Published studies have explored ozonated water’s antibacterial properties and potential applications in oral and skin care. Research continues to investigate its effectiveness and safety across different uses.Citation
Mohandas R, Mohapatra S, Krishnan RP. Ozonated water as a preventive oral hygiene aid: a systematic review and meta-analysis of its role in reducing dental plaque. Evidence-Based Dentistry. 2026;27(3):84–85. doi:10.1038/s41432-026-01245-9.
Conclusion
Ozonated water may help reduce dental plaque in the short term, but the available evidence is not yet sufficient to establish superiority over standard mouthrinses or plain water.
Citation
Hemgude P, Reshma M, Baldev R, et al. Comparative Evaluation of Ozonized Water and Alkaline Water on Plaque and Gingival Index in the Oral Cavity: An in vivo Study. Journal of Pharmacy and Bioallied Sciences. 2025;17(Suppl 4):S3238–S3240. doi:10.4103/jpbs.jpbs_1309_25.
Conclusion
In this randomized controlled in vivo study, ozonized water used twice daily for four weeks was associated with significant reductions in plaque and gingival indices compared with the control group.
Citation
Takizawa F, Domon H, Hiyoshi T, et al. Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment. PLOS ONE. 2023;18(4). doi:10.1371/journal.pone.0284115.
Conclusion
In vitro experiments showed that ozone ultrafine bubble water reduced multiple oral and upper-airway pathogens by more than 99% under specific exposure conditions. The study also found no significant cytotoxicity toward the tested human gingival epithelial cell line.
Citation
Leon BR, Romary DJ, Landsberger SA, et al. Risks of ozonated oil and ozonated water on human skin: A systematic review. International Wound Journal. 2022;19(7):1901–1910. doi:10.1111/iwj.13760.
Conclusion
This systematic review of nine studies found no significant dermatological risks associated with the evaluated ozonated liquids. However, larger and longer-term clinical studies are needed to further establish their safety.
Citation
Kaneki M, Ohira C, Takahashi M, et al. Therapeutic potential of ozone water treatment in alleviating atopic dermatitis symptoms in mouse models: Exploring its bactericidal and direct anti-inflammatory properties. International Immunopharmacology. 2023;124(Pt A):110920. doi:10.1016/j.intimp.2023.110920.
Conclusion
Laboratory experiments demonstrated antibacterial activity against staphylococcal bacteria. The study also observed anti-inflammatory effects in experimental skin models, suggesting potential dermatological applications that require further clinical investigation.
Citation
Zeng J, Dou J, Gao L, et al. Topical ozone therapy restores microbiome diversity in atopic dermatitis. International Immunopharmacology. 2020;80:106191. doi:10.1016/j.intimp.2020.106191.
Conclusion
This randomized human study found improvements in atopic dermatitis severity and skin microbial diversity following topical ozone treatment combining ozonated water and ozonated oil. The individual effects of ozonated water could not be determined separately.applications.